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. 2012 Jul 5;5(5):636–648. doi: 10.1242/dmm.009266

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© 2012. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 6. — Inflammation markers and renal injury in the four genotypes. (A) Immunostaining for MCP-1, TGFβ, PTHrP and type IV collagen in the kidney from male WT, PPARγ2 KO, ob/ob and POKO mice at 4 weeks (n=4–5). Original magnification: 400×; scale bars: 50 μm. (B) Representative immunoblot for cytosolic (CE) and nuclear (NE) p65 NFκB protein in renal extracts from WT, PPARγ2 KO, ob/ob and POKO 4-week-old male mice. Levels were normalized to β-actin in the cytosolic fraction and lamin-β receptor in the nuclear fraction. Each value is the relative optical intensity of each band normalized as a percentage of that of the WT group. Values are represented in graphic (n=5–7). Data are means±s.e.m. **P<0.01 POKO vs ob/ob; ^##P<0.01 POKO vs WT; ^ΨP<0.05 POKO vs PPARγ2 KO.