Table 3. Recommendations from the 2007 guidelines for management of severe traumatic brain injury[2-13].

Parameters	Recommendations
Blood pressure	Monitor and avoid hypotension (Systolic Blood Pressure < 90 mmHg). (level II)
Oxygenation	Monitor and avoid hypoxia (PaO2 < 60 mmHg or oxygen saturation < 90%) (level III)
Hyperventilation	Prophylactic hyperventilation (PaCO2 ≤ 25 mmHg) is not recommended. (level II) Hyperventilation is recommended as a temporizing measure for the reduction of elevated intracranial pressure. (level III)
Hyperosmolar therapy	Mannitol (0.25 - 1.0 g/kg) is effective for control of raised intracranial pressure. Hypotension should be avoided. (level II) Restrict mannitol use prior to intracranial pressure monitoring to patients with signs of transtentorial herniation or progressive neurological deterioration not attributable to extracranial causes. (level III)
ICP	ICP should be monitored in patients with severe TBI and abnormal CT scan (level II) and in patients with normal CT scan if two or more of following are present: age > 40 years, motor posturing, systolic blood pressure < 90 mmHg (level III). Treatment should be initiated if intracranial pressure is > 20 mmHg (level II)
Temperature	Prophylactic hypothermia is not significantly associated with decreased mortality. (level III) Hypothermia may have higher chances of reducing mortality when cooling is maintained for more than 48 hours. (level III)
CPP	Maintain cerebral perfusion pressure between 50-70 mmHg. Avoid aggressive treatment with fluid and pressors to maintain CPP > 70 mmHg. (level II) Avoid CPP < 50 mmHg. (level III)
Brain Oxygenation	Treat when SjvO2 < 50% or brain tissue oxygen tension < 15 mmHg. (level III)
Steroids	In patients with moderate or severe TBI, high-dose methylprednisolone is associated with increased mortality and is contraindicated. (level I)