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. 2012 Aug 20;2:10.3402/pba.v2i0.19182. doi: 10.3402/pba.v2i0.19182

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© 2012 Christina Pettan-Brewer et al.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2 — Subcutaneous B16 melanoma tumors in C57BL/6 mice are histologically more aggressive in young animals compared to old animals as determined from hematoxylin and eosin stained slides. (A) The main histological features in 8-month-old mice were high neovascularization, high mitotic activity, and lack of any surrounding confining borders (40× and 200× power). (B) The main histological features in 32-month-old mice were presence of a fibrous capsule, few mitotic figures, and low vascularity (40× and 200× power).