Table 3.
Median Levels of Immune Markers in the Oral-Immunotherapy Group, According to the Responses to Three Oral Food Challenges.
| Variable | Month 10 | Month 22 | Month 24 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Pass (N = 22) |
Fail (N = 18)* |
P Value | Pass (N = 30)† |
Fail (N = 10)‡ |
P Value | Pass (N = 11)§ |
Fail (N = 29)¶ |
P Value | |
| Month 10 | |||||||||
| Wheal diameter on skin-prick testing (mm) | 3.8 | 6.0 | 0.10 | 4.0 | 7.0 | 0.03 | 4.0 | 5.5 | 0.32 |
| Egg-specific IgG4 antibody (mg/liter) | 52.0 | 14.2 | 0.007 | 42.6 | 7.6 | 0.005 | 54.8 | 22.4 | 0.02 |
| Total IgE antibody (kU/liter) | 1205.9 | 926.4 | 0.68 | 1177.6 | 859.6 | 0.77 | 1246.5 | 915.2 | 0.67 |
| Egg-specific IgE antibody (kU/liter) | 7.5 | 6.1 | 0.38 | 5.3 | 13.3 | 0.02 | 5.2 | 6.8 | 0.35 |
| CD63+ basophils (%) | |||||||||
| 0.1 µg of egg extract | 2.1 | 9.7 | 0.05 | 1.9 | 29.3 | 0.008 | 2.5 | 2.8 | 0.70 |
| 0.01 µg of egg extract | 1.0 | 2.7 | 0.19 | 0.5 | 6.1 | 0.04 | 1.4 | 0.9 | 0.62 |
| Month 22 | |||||||||
| Wheal diameter on skin-prick testing (mm) | — | — | 1.8 | 7.0 | 0.009 | 0.0 | 5.5 | 0.005 | |
| Egg-specific IgG4 antibody (mg/liter) | — | — | 53.6 | 7.4 | 0.02 | 55.7 | 30.8 | 0.14 | |
| Total IgE antibody (kU/liter) | — | — | 728.2 | 747.3 | 0.89 | 991.5 | 707.3 | 0.82 | |
| Egg-specific IgE antibody (kU/liter) | — | — | 3.0 | 5.8 | 0.07 | 3.7 | 4.0 | 0.39 | |
| CD63+ basophils (%) | |||||||||
| 0.1 µg of egg extract | — | — | 0.7 | 19.5 | 0.006 | 0.8 | 3.1 | 0.52 | |
| 0.01 µg of egg extract | — | — | 0.6 | 10.6 | 0.07 | 0.8 | 0.9 | 0.82 | |
Data on CD63+ basophils (i.e., the overall percentage of basophils that were CD63+) were missing for three children.
Data on CD63+ basophils at month 10 were missing for one child, data on total IgE antibody at month 22 were missing for three, and data on CD63+ basophils at month 22 were missing for two.
Data on CD63+ basophils at month 10 were missing for two children; data on wheal diameter on skin-prick testing, egg-specific IgG4 antibody, total IgE antibody, and egg-specific IgE antibody at month 22 were missing for two; and data on CD63+ basophils at month 22 were missing for one.
Data on CD63+ basophils at month 22 were missing for two children.
Data on CD63+ basophils at month 10 were missing for three children; data on total IgE antibody at month 22 were missing for five; data on wheal diameter on skin-prick testing, egg-specific IgG4 antibody, and egg-specific IgE antibody at month 22 were missing for two; and data on CD63+ basophils at month 22 were missing for one.