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. 2012 Jul 25;32(30):10396–10407. doi: 10.1523/JNEUROSCI.6474-11.2012

Figure 1.

Figure 1.

RhoA–Olig2–CKO mice exhibit a rabbit-like hopping gait and nerve fibers that aberrantly cross the spinal cord midline. A, Hindlimb footprint patterns of control and RhoA–Olig2–CKO mice. B, C, Nissl-stained sections of the spinal cords of 3-week-old mice. The central canal appeared to be split into two parts, and the gray matter was expanded in RhoA–Olig2–CKO mice. D, E, H, Anterograde tracing of the CST by BDA. Some CST axons aberrantly crossed the midline and projected to the other side of the spinal cord in RhoA–Olig2–CKO mice (arrowheads). F, G, F′, G′, I, Tracing of spinal interneurons by RDA. Numerous interneurons also projected to the contralateral side in RhoA–Olig2–CKO mice (arrowheads). H, I, Bar graphs showing the number of neuronal projections across the midline of the spinal gray matter. The graphs represent the mean ± SD of three to five mice. **p < 0.01, Student's t test. CC, Central canal. Scale bars, 100 μm.