Figure 4.

RhoA plays a role in the survival of motor neurons in the developing spinal cord. A–D, I, J, The number of Isl1/2⁺ motor neurons in RhoA–Olig2–CKO embryos was not significantly different from that of control embryos at E10.5 but was significantly decreased at E12.5. E–H, K, L, The number of TUNEL⁺ cells among the Isl1/2⁺ motor neurons in RhoA–Olig2–CKO embryos was also similar to that of control embryos at E10.5, but, at E12.5, TUNEL⁺ cells showed a significant increase. The graphs represent the mean ± SD of three to six embryos. *p < 0.05, **p < 0.01, Student's t test. DRG, Dorsal root ganglion. Scale bars, 50 μm.