Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 May 10;40(15):7358–7367. doi: 10.1093/nar/gks407

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 4. — Replication challenge increases UFB formation. (A) IF-FISH images from IMR90-E6E7 and AG05229-E6E7 fibroblast cells. Arrows indicate colocalization events at BLM bridges observed in interphase cells. (B) Average number of BLM foci per cell. At least 100 cells were counted per condition from three independent experiments. (C) Percentage UFB-positive anaphases and (D) percentage of UFBs extending from telomeres (T-UFBs) in IMR90-E6E7 and AG05229-E6E7 cells treated with ethanol or aphidicolin. At least 30 anaphases were counted per condition from three independent experiments. (E) Percentage of UFBs and (F) UFBs that extend from telomeric foci (T-UFBs) on TRF1 suppression. At least 35 anaphases were counted per cell line from two independent experiments. Arrow bars show standard deviation, and P-values were calculated from a Student’s t-test (*P < 0.05 and **P < 0.005).