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. 2012 May 17;40(15):7257–7268. doi: 10.1093/nar/gks429

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — The effects of enforced silencing by tTS on methylation seeding and spreading. (A) Comparing the methylation profiles of pINSL6 in SW48A/tTS and SW48A cells (150 days). **Significantly different methylation of each transgene between host cells (P < 0.01). (B) Comparison of methylation and GFP expression between tet(−)-pINSL6 in SW48A/tTS, tetO(+)-pINSL6 in SW48A and tetO(+)-pINSL6 in SW48A/tTS. Pyrosequencing was performed for transgenes (No-frag and RILUP) at 60 and 90 days; flow cytometry was used to detect GFP expression at 60 days.