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. 2012 May 22;40(15):7113–7122. doi: 10.1093/nar/gks465

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Nucleotide variations between H₃₇Rv and H₃₇Ra manifest in changes in GRAVY values. GRAVY values of PE/PPE proteins in H₃₇Rv and their homologs in H₃₇Ra were plotted where ΔGRAVY was >50%. (A) A major transition from hydrophobic to hydrophilic protein is observed in Rv2408/MRA_2433 and Rv0878c/MRA_0885, whereas Rv2371/MRA_2394 only showed a significant difference in GRAVY value. A hydrophilic to hydrophobic transition was observed in Rv0388c/MRA_0395. (B) Non-PE/PPE proteins. H₃₇Rv proteins MMPL13b (Rv1146), SigM (Rv3911), PhoP (Rv0757) and their homologs in H₃₇Ra (MRA_1156, MRA_3950, MRA_0767), respectively. ΔGRAVY value >50% was observed only in case of Rv3911/MRA_3950.