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. 2012 May 22;40(15):7113–7122. doi: 10.1093/nar/gks465

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Variations in nucleotide sequences between H₃₇Rv and H₃₇Ra affect the stability of PE/PPE proteins but not the non-PE/PPE proteins. Instability index value >40 is indicative of unstable protein and value <40 means the protein is stable. (A) PE/PPE proteins in H₃₇Rv and their homologs in H₃₇Ra show a change from stable to unstable (Rv1091/MRA_1102 and Rv2408/MRA_2433) or the reverse (Rv1195/MRA_1205 and Rv1807/MRA_1819). (B) Non-PE/PPE proteins MMPL13b (Rv1146), SigM (Rv3911), PhoP (Rv0757), and their homologs in H₃₇Ra (MRA_1156, MRA_3950, MRA_0767), respectively, did not show any transition from stable to unstable or reverse.