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. 2012 Jun 20;40(15):e114. doi: 10.1093/nar/gks543

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Flowchart of i-cisTarget. The 136K regions are scored in batch (i.e. offline) with collections of PWMs and iVEs, yielding PWM and iVE rankings respectively. An input set of genes or genomic loci is mapped to the 136K set to obtain a set of foreground sequences. The enrichment of the foreground sequences is calculated in all rankings using recovery curves and statistics. Top ranking regions for enriched features represent candidate CRMs.