. Author manuscript; available in PMC: 2012 Aug 22.

Published in final edited form as: Med Clin North Am. 2010 May;94(3):447–464. doi: 10.1016/j.mcna.2010.02.009

Table 4.

Randomized controlled trials studying effect of positive airway pressure therapy in patients with CHF and obstructive sleep apnea

First Author	Year	Number of CHF Patients	Intervention	Duration of Intervention	Control	Results
Egea⁵⁶	2008	60	CPAP	3 mo	Sham CPAP	Improvement in LVEF
Mansfield⁵⁷	2004	55	CPAP	3 mo	Medical therapy for CHF	Significant improvement in LVEF and QOL, reduction in overnight UNE
Kaneko⁵⁸	2003	24	CPAP	1 mo	Medical therapy for CHF	Improvement in LVEF, reduction in LVESD
Smith⁶⁰	2007	26	Autotitrating CPAP	6 wk	Sham CPAP	Improvement in daytime sleepiness, but not in LVEF or exercise capacity
Khayat⁶²	2009	46	Autotitrating CPAP	3 d	Medical therapy for decompensated CHF	Significant improvement in LVEF

Abbreviations: CPAP, continuous positive airway pressure; LVEF, left ventricular ejection fraction; LVESD, left ventricular end-systolic diameter; QOL, quality of life; UNE, urinary norepinephrine excretion.