Table 2.
Major inherited diseases of sodium channels
| Disease | Gene | Channel |
|---|---|---|
| Generalized epilepsy with febrile seizures plus | SCN1A | Nav1.1 |
| Dravet syndrome (severe myoclonic epilepsy in infancy) | SCN1A | NaV1.1 |
| Benign neonatal convulsions | SCN1A | NaV1.1 |
| Familial hemiplegic migraine type III | SCN1A | NaV1.1 |
| Benign familial neonatal–infantile seizures | SCN2A | NaV1.2 |
| Hypokalaemic periodic paralysis type II | SCN4A | Nav1.4 |
| K+-sensitive normokalaemic periodic paralysis | SCN4A | Nav1.4 |
| Hyperkalaemic periodic paralysis | SCN4A | Nav1.4 |
| Paramyotonia congenita | SCN4A | NaV1.4 |
| Long QT syndrome type III | SCN5A | Nav1.5 |
| Brugada syndrome | SCN5A | NaV1.5 |
| Erythromelalgia | SCN9A | NaV1.7 |
| Paroxysmal extreme pain disorder | SCN9A | NaV1.7 |
| Congenital indifference to pain | SCN9A | NaV1.7 |