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. 2012 Apr 10;590(Pt 11):2801–2809. doi: 10.1113/jphysiol.2011.227090

Table 2.

Heart rate and blood pressure, prior to and during normoxic and hypoxic gas breathing, with and without sympathetic inhibition (48 h transdermal clonidine)

Normoxia (Inline graphic = 0.21) Hypoxia (Inline graphic = 0.11)


No clonidine Clonidine No clonidine With clonidine




Prior to During Prior to During Prior to During Prior to During
HR (b min−1) 59 ± 3 68 ± 2 55 ± 4 61 ± 3 57 ± 2 84 ± 4 49 ± 2 76 ± 3
SBP (mmHg) 120 ± 3 124 ± 3 110 ± 3 114 ± 3 123 ± 3 122 ± 2 113 ± 3 125 ± 9
DBP (mmHg) 72 ± 2 71 ± 2 67 ± 3 64 ± 3 75 ± 3 68 ± 2 66 ± 2 63 ± 2

Data are means ± SEM. ‘Prior to’ data collected before breathing normoxic or hypoxic gas. ‘During’ data are averaged values collected throughout the entire hyperinsulinaemic euglycaemic clamp procedure (180 min). See text for details pertaining to statistical analysis. SBP: systolic blood pressure. DBP: diastolic blood pressure.