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. 2012 May 16;109(3):137–145. doi: 10.1038/hdy.2012.24

Figure 5.

Figure 5

Results from the second program (distributions of mutational effects). Left figures show the marginal distributions of s1 and s2 (which now measure effects of mutations in the heterozygous state); right figures show mean fitness as a function of α, for different values of the correlation coefficient ρ between s1 and s2: ρ=0 (filled squares), 0.5 (empty squares), 0.8 (empty circles, bottom figure only) and 1 (filled circles). The mean mutational effects are fixed to 0.0005 in environment 1 and 0.005 in environment 2. Other parameters are n=100, N=500, m=0.05, K (number of chromosomes) =10, R/K, U/K (chromosome map length and mutation rate per chromosome) =0.1, nL (number of loci) =105. SD of the distributions of log10(s1), log10(s2): 0.2 (top), 0.5 (middle), 1 (bottom).