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Environmental-responsive controlled release system for sustained bFGF delivery in ischemic tissue triggered by pH. TEM micrography of heparinized chitosan/poly(gamma-glutamic acid) (HP-CS/g-PGA) nanoparticles at a distinct pH value: (A) pH 6.0 (after 2 h), (B) pH 7.4 (after 10 min), (C) pH 7.4 (after 30 min), (D) pH 7.4 (after 2 h). (E) Release of bFGF or heparin from the smart nanoparticles, depending on the environmental pH variation. Reproduced with permission from ref 37.
