Table 2.
Overview of ranges during pregnancy per tumor marker.
| Normal oncologic cut-off values in non-pregnant women | Trimester 1a | Trimester 2 | Trimester 3 | References | |
|---|---|---|---|---|---|
| Carbohydrate antigen 15-3b | <30 U/mL | 5.0 to 39.3 | 1.0 to 40 | 7.0 to 56 | [7,11,51,52] |
| 1.3 to 19.5 | 4.0 to 24.4 | 7.0 to 27 | [6,7] | ||
| Squamous cell carcinoma antigen | <2 µg/L | 0.3 to 2.9 | 0.1 to 2.2 | 0.6 to 4.3 | [7] |
| 0 to 1.97 | 0.51 to 1.99 | 0 to 2.22 | [6] | ||
| Carbohydrate antigen 125 | <39 U/mL | 3.7 to 550 | 1 to 166.6 | 6.1 to 2,419.7 | [7,10,11,13,14,17,18] |
| 0 to 215.1 | 0 to 308 | 0 to 56.3 | [15,16] | ||
| Inhibin B | ng/mL | NA | NA | NA | NA |
| 22.06 to 32.94 | 19.88 to 56.12 | 58.62 to 171.38 | [19] | ||
| Anti-Müllerian hormone | ng/mL | 0.2 to 9.3 | 0.5 to 4.0 | 0.2 to 3 | [22,23] |
| NA | NA | NA | NA | ||
| Lactate dehydrogenase | <221 U/L | 78 to 433 | 80 to 447 | 82 to 524 | [25-28] |
| NA | NA | NA | NA |
NA, not applicable. aThe definition of first, second and third trimester is the one used in the study and differs from one study to the other; b for each parameter the non-pregnant reference value is the mean of all studies, whereas lowest and highest ranges and 2.5 to 97.5 percentiles in the three pregnancy trimesters are presented in the first and the second row, respectively.