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Structure-activity relationship for various cyclin D1 binding peptides
 | ||||
|---|---|---|---|---|
| SEQUENCE | IC50 CDK2/A2(µM) |
Potency ratio |
IC50 CDK4/D1(µM) |
Potency ratio |
| SAKRRLFG | 3.3 | 2.9 | ||
| HAKRRLIF | 1.3 | 1.5 | ||
| RRLIpfF | 26 | 20.0 | 250 | 166.7 |
| HAKCitRLIF | 18 | 13.8 | 21 | 14.0 |
| HAKTRLIF | 50 | 38.5 | 25 | 16.7 |
| CitRLIF | 164 | 126.2 | 179 | 119.3 |
| SCCP10 | 25 | 19.2 | 8 | 5.3 |
| SCCP 5624 | >100 | 60 | 20.7 | |
| SAKRNLFGM | 146 | |||
| SAKRNLFG | 75 | |||
| SAKRALFGM | 68 | |||
| PAKRRLFG | 8 | 6.7 | ||
| PVKRRLFG | 3 | 28 | ||
| PVKRRL3CFG | 1 | 3.2 | ||
