Table 1.
Overview of the M. tuberculosis and M. leprae transporter analyses based on TC class and subclass
| TC classa | Class description | No. of transport proteinsb | Mle/Mtuc | TC subclass | Subclass description | No. of transport proteins | Mle/Mtu | ||
|---|---|---|---|---|---|---|---|---|---|
| Mtu | Mle | Mtu | Mle | ||||||
| 1 | Channels | 8 (8) | 3 (3) | 38% | 1.A | α-Type channels | 6 (6) | 2 (2) | 33% |
| 1.B | β-Barrel porins | 2 (2) | 1 (1) | 50% | |||||
| 2 | Secondary carriers | 82 (78) | 26 (23) | 29% | 2.A | Porters (uniporters, symporters, antiporters) | 82 (78) | 27 (23) | 29% |
| 3 | Primary active transporters | 132 (46) | 72 (24) | 52% | 3.A | P–P-bond-hydrolysis-driven transporters | 111 (43) | 66 (23) | 53% |
| 3.D | Oxidoreduction-driven transporters | 21 (3) | 6 (1) | 33% | |||||
| 4 | Group Translocaters | 1 (1) | 0 (0) | 0% | 4.C | Acyl-CoA ligase-coupled transporters | 1 (1) | 0 (0) | 0% |
| 5 | Transmembrane electron carriers | 8 (4) | 1 (1) | 25% | 5.A | Transmembrane two-electron transfer carriers | 8 (4) | 1 (1) | 25% |
| 8 | Auxiliary transport proteins | 1 (1) | 1 (1) | 100% | 8.A | Auxiliary transport proteins | 1 (1) | 1 (1) | 100% |
| 9 | Poorly defined systemsd | 53 (9) | 33 (3) | 33% | 9.A | Recognized transporters of unknown biochemical mechanism | 53 (9) | 33 (3) | 33% |
| Total | 285(147) | 136 (55) | 37% | 285 (147) | 136 (55) | 37% | |||
a
Transporter classes 6 and 7 have not been assigned in the TC system and therefore are absent.
b
Numbers in parentheses represent the number of transport systems. Transport systems are comprised ofone or more constituent transport proteins.
c
Relative reduction in transport systems from Mtu to Mle.