Table 2.
Overview of transport systems in M. tuberculosis and M. leprae based on predicted substrate specificity
| Substrate Category | Mtu | Mle | Mle/Mtua | Substrate Subcategory | Mtu | Mle | Mle/Mtu | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Organic | 63 | 37% | 21 | 36% | 33% | AA/peptides | 18 | 11% | 4 | 7% | 22% |
| Drugs | 31 | 18% | 12 | 21% | 39% | ||||||
| Carboxylates | 5 | 3% | 0 | 0% | 0% | ||||||
| Nucleotides/Nucleosides | 1 | 1% | 0 | 0% | 0% | ||||||
| Sugars | 7 | 4% | 4 | 7% | 57% | ||||||
| Vitamins | 1 | 1% | 1 | 2% | 100% | ||||||
| Inorganic | 57 | 34% | 22 | 38% | 39% | Anions | 20 | 12% | 6 | 10% | 30% |
| Cations | 32 | 19% | 15 | 26% | 47% | ||||||
| Electrons | 5 | 3% | 1 | 2% | 20% | ||||||
| Macromolecule | 27 | 16% | 12 | 21% | 44% | DNA/DNA-protein complexes | 1 | 1% | 1 | 2% | 100% |
| Lipooligosaccharides/polysaccharides | 2 | 1% | 1 | 2% | 50% | ||||||
| Proteins/lipoproteins | 13 | 8% | 7 | 12% | 54% | ||||||
| Lipids | 11 | 6% | 3 | 5% | 27% | ||||||
| Total | 147 | 100% | 55 | 100% | 37% | 147 | 100% | 55 | 100% | 37% | |
a
Relative reduction in transport systems from Mtu to Mle