. Author manuscript; available in PMC: 2013 Mar 1.

Published in final edited form as: Biochim Biophys Acta. 2011 Nov 29;1818(3):776–797. doi: 10.1016/j.bbamem.2011.11.015

Table 3.

TC classification and functional predictions of putative transport proteins from M. tuberculosis and M. leprae

		Transport Classification (TC)						M. tuberculosis (Mtu)						M. leprae (Mle)				Mtu/Mle

Family TC#	Family name	Transport System TC#	No. of comp.^a	Acc. # in TCDB^b	Size (aa)	TC TMS^c	Comments	GI # (CDC1551)	GI # (H37Rv)	Size (aa)	TMS	% Identity Mtu/TC	Comments (Mtu vs. TC)	GI #	Size (aa)	TMS	% Identity Mle/TC	% Identity Mtu/Mle	No. of transport systems
																			Mtu^e	Mle^f
1.A alpha-Type Channel-forming Proteins and Peptides

1.A.1	(VIC) Superfamily	1.A.1.13.2	1	O27564	336	2		15842786	15610336	355	2	26	Mtu-N: [1,2,3]	-	-	-	-	-	1	0

1.A.11	Ammonia Channel Transporter (Amt) Family	1.A.11.1.3	1	Q79VF1	438	10		15842463	15610057	477	10	52	Mtu-C: [1,2]	-	-	-	-	-	1	0

1.A.22	Large Conductance Mechanosensitive Ion Channel (MscL) Family	1.A.22.1.2	1	O53898	151	2		15840410	15608125	151	2	100		15826991	154	2	71	70	1	1

1.A.23	Small Conductance Mechanosensitive Ion Channel (MscS) Family	1.A.23.3.1	1	O34897	267	2		15842675	15610241	308	2	30		-	-	-	-	-	2	0
1.A.23		1.A.23.4.1	1	Q58543	361	6		15841954	15609571	481	6	24	Mtu-C: Crp(31008), CAP_ED(28920)[1,2,3,4]	-	-	-	-	-

1.A.35	CorA Metal Ion Transporter (MIT) Family	1.A.35.3.1	1	Q58439	317	3		15840684	15608379	366	3	19	Mtu-N: [1,2,3,4]	15827535	369	3	19	79	1	1

1.B Outer Membrane Porins (beta-structure)

1.B.6	OmpA-OmpF Porin (OOP) Family	1.B.6.1.3	1	P65593	326	1		15840318	15608039	326	1	100		-	-	-	-	-	1	0

1.B.50	Acid-fast Bacterial, Outer Membrane Porin (AFB-OMP)	1.B.50.1.1	1	P64883	314	1		15841155	15608836	314	1	100	Rv1698 (H37Rv)	15827709	317	1	-	56	1	1

2.A Carrier-type Facilitators

2.A.1	Major Facilitator Superfamily (MFS)

	SP	2.A.1.1.1	1	P37021	464	12		15842926	15610467	500	12	30	Mtu-N: [1,2]	-	-	-	-	-	1	0

	DHA1 (12-Spanner)	2.A.1.2.7	1	Q9S3J9	395	12		15840256	15607982	442	12	21	Mtu-N: [1] Mtu-C: [1]	-	-	-	-	-	2	0
								15839570	15607332	413	12	32		-	-	-	-	-

	DHA2 (14-Spanner)	2.A.1.3.5	1	Q54806	501	14		15841836	15609470	537	14	32	Mtu-C: [1,2]	-	-	-	-	-	12	2
		2.A.1.3.11	1	P42670	503	14		15841089	15608772	471	14	28	Mtu-C: [1,2]	-	-	-	-	-
								15842387	15609983	530	14	34	Mtu-N: [1,2]	15827823	534	14	34	86
		2.A.1.3.12	1	P39886	538	14		15840696	15608390	579	14	32	Mtu-C: [1,2]	-	-	-	-	-
								15841347	15609014	687	14	30	Mtu-N: [] Mtu-C: [1,2,3,4]	-	-	-	-	-
								15841983	15609596	523	14	31		-	-	-	-	-
								15842828	15610375	1065	14	32	Mtu-N: [1,2] Mtu-C: RssA(31938), CAP_ED(28920)[1,2,3,4]	-	-	-	-	-
								15843349	15610864	1071	14	34	Mtu-N: [1,2] Mtu-C: RssA(31938), CAP_ED(28920)[1,2,4]	-	-	-	-	-
								15840198	15607923	545	14	26		-	-	-	-	-
		2.A.1.3.25	1	Q9HS33	420	12		15841758	15609402	409	12	20	Mtu-N: [1,2,3]	-	-	-	-	-
								15841980	15609593	418	12	24	Mtu-N: [1,2,4]	-	-	-	-	-
		2.A.1.3.32	2	P71678	518	14		15840868	15608548	518	14	28		15827207	509	14	27	82
				P0A5I8	236	1		15840869	15608549	236	1	100		15827208	238	1	100	68

	MHS	2.A.1.6.3	1	Q52000	429	12		15843086	15610612	449	12	40		-	-	-	-	-	3	0
								15840290	15608016	559	12	28	Mtu-N: [1,2,3,4] Mtu-C: [1,2,3,4]	-	-	-	-	-
		2.A.1.6.6	1	P76350	438	12		15840644	15608340	425	12	36		-	-	-	-	-