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. Author manuscript; available in PMC: 2012 Aug 22.
Published in final edited form as: Nature. 2007 Dec 20;450(7173):1195–1200. doi: 10.1038/nature06416

Figure 3.

Figure 3

Crosstalk with synaptically-induced plasticity

(a) Schematic of the experiment.

(b) Images before (−3′) and after (1′) the synaptic LTP protocol (applied at time = 0; 120 stimuli, 2 Hz in low extracellular Mg2+). The arrowhead marks an enlarged spine (synaptic LTP spine). A ratio image (ΔF/F) comparing fluorescence intensity before (−3′) and after (1′) the synaptic LTP protocol is shown.

(c) High zoom images before (−3′) stimulation, after (1′) the synaptic LTP protocol (applied at time = 0), and after (21′) the subthreshold protocol (applied at time = 2 minutes). A circle, square, and triangle mark the synaptic LTP spine, the sub spine, and a nearby spine, respectively.

(d) Changes in spine volume for the example shown in (b-c).

(e) Time-course of the change in spine volume for synaptic LTP spines (n = 11), sub spines (n = 11), and nearby spines (n = 34), mean ± sem.