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. 2012 Aug 17;61(9):2289–2298. doi: 10.2337/db11-1395

FIG. 1.

FIG. 1.

Gpc4 is differentially regulated in subcutaneous and visceral WAT upon weight gain. A: Gpc4 expression in subcutaneous (SCW) and visceral (Visc.) fat of 77 female and 83 male nondiabetic subjects, ranging from lean to obese, grouped by BMI. Visc. BMI 25–30 and visc. BMI >30 indicates subjects with a CT or MRI ratio between subcutaneous and visceral fat areas >0.4 in the given BMI range. B: Western blot for Gpc4 from 6-week-old C57BL/6 male mice. Actin is used as loading control. C: qPCR for Gpc4 from the indicated fat depots of C57BL/6 mice fed an HFD for 8 weeks, db/db and control mice. Control mice are C57BL/6 chow diet–fed mice and db/+ mice combined (HFD, n = 4; db/db, n = 6; controls, n = 4–6). BAT, brown adipose tissue; PGF, perigonadal fat; SCF, subcutaneous flank fat. *P < 0.05; **P < 0.01; ***P < 0.001.