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. 2012 Aug 17;61(9):2320–2329. doi: 10.2337/db11-1179

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© 2012 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 4. — In vitro KH064 inhibits palmitic acid–induced PGE₂ production in human immune cells. The production of PGE₂ in culture supernatants was analyzed by ELISA. HMDM, PBMC, Jurkat, HMC-1, and THP-1 secrete PGE₂ elicited by palmitic acid (PA) and pretreatment of KH064 inhibits this palmitic acid–induced PGE₂ production. Error bars represent mean ± SEM of least three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001.