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. 2012 Jul 25;32(30):10253–10266. doi: 10.1523/JNEUROSCI.0581-12.2012

Figure 7.

Figure 7.

Synergism between Aβ/APP and tau is required to elevate αSyn protein levels in vivo. A, Quantitative Western blot analysis of αSyn, SYP, and actin using soluble brain extracts from 3- and 8-month-old nontransgenic (CTL), Tg2576 (Aβ), rTg4510 (Tau), and Tg2576xrTg4510 (AβxTau) mice. B, Quantification of SYP mirrors neuronal toxicity previously reported in rTg4510. Values represent mean ± SD (n = 3–4 per age per genotype; ANOVA followed by Fisher's PLSD test). C, Quantification of soluble αSyn protein levels revealed no apparent changes with aging in wild-type, Tg2576, and rTg4510 mice. In contrast, an ∼1.6-fold increase of αSyn was observed in 8-month-old Tg2576xrTg4510 compared with 3-month-old animals. Open and filled bars represent data at 3 and 8 months, respectively. Values represent mean ± SD (n = 3–4 per age per genotype; ANOVA followed by Fisher's PLSD test).