Table 3. Serological and virological characteristics of subjects with occult hepatitis C virus (HCV) infection.
N | SEX | AGE | DISEASE | HBV status | AST ALT* | GGT ALP** | Liver functional tests*** | HCV antibodies | HCV-RNA plasma | HCV-RNA PBMCs | HCV genotype | VIRAL LOAD PBMCs§ (IU/ml) |
1 | M | 71 | SE | neg | −/− | −/− | normal | − | − | + | n.d. | 1,55E+02 |
2 | M | 57 | SE | neg | −/− | −/− | normal | − | − | + | n.d. | 6,47E+01 |
3 | M | 69 | SE | POS | −/− | −/− | normal | − | − | + | n.d. | 1,40E+02 |
4 | F | 28 | PV | neg | +/+ | −/− | normal | − | − | + | 2a/2c | 1,71E+04 |
5 | F | 81 | SE | neg | −/− | −/− | normal | − | − | + | 1b | 3,24E+02 |
6 | M | 73 | SE | POS | −/− | −/− | normal | − | − | + | 1b | 2,39E+05 |
AST and ALT values at recruitment; −/−: normal values of AST: below 40 IU/L and 32 IU/L for men and women respectively, and ALT: below 50 IU/L and 35 IU/L for men and women respectively. +/+ altered levels of AST and ALT.
GGT and ALP values; −/−: normal values of GTT: below 50 IU/L and 35 IU/L for men and women respectively, and ALP: below 128 IU/L and 141 IU/L for men and women respectively.
Liver functional tests: total plasma protein, albumin, cholesterol, total and fractionated bilirubin, prothrombin time, partial thromboplastin time, and international normalised ratio.
PBMCs viral load on baseline sample.
Abbreviations: SE, secondary erythrocytosis; PV, polycythemia vera; HBV, hepatitis B virus; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, gamma glutamyl transpeptidase; ALP, alkaline phosphatase, n.d., not determined because the amplification resulted in a very weak fragment and sequence analysis did not succeed; PBMCs, peripheral blood mononuclear cells.