Figure 8. Observation of different dynamical scenario for the parameter set obtained from fitting the time series data by global optimization.

Loss of mushroom-like dynamics in the full ordinary differential equation (ODE) model with as the bifurcation parameter. (A) The Z-shaped bistability is lost, but ultrasensitivity is retained. A mushroom-like dynamics is possible without any memory effect at high chronic stress due to loss of Z-shaped bistability. (B) Irreversible transition in the S-shaped bistability is observed. Z-shaped bistability is lost and it is replaced by Hopf bifurcation with a very low period. The parameters used to simulate the dynamics for each of the cases are given in a separate file (Model file S2).