Table-1.
Increased p202 protein levels and its nuclear localization are associated with the production of ANAs and IFN-α, and reduced levels of the FcγRIIB and Slamf1 receptors.
| Mouse strain | Nba2 genes | IFN-α levelsa | Protein levels FcγRIIB | Protein levels Slamf1 | Protein levels p202 | ANAsb |
|---|---|---|---|---|---|---|
| B6 | None | Not detected | +++ | +++ | + (C) | Not detected |
| B6.Nba2-ABC | FcγRs, Slam, and Ifi200 | Detectable | + | + | +++ (N) | Yes (+++) |
| B6.Nba2-A′B | FcγRs, Slam | Detectable | ? | ? | + (?) | Yes (++) |
| B6.Nba2-C | Ifi200 | Not detected | +++ | +++ | − | Not detected |
a
Serum levels of IFN-α at the age of 7–8 months;
b
ANAs against chromatin, histones, and dsDNA;
C, cytoplasmic; N, Nuclear.