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. Author manuscript; available in PMC: 2013 Aug 1.

Published in final edited form as: Horm Behav. 2012 Mar 31;62(3):202–209. doi: 10.1016/j.yhbeh.2012.03.010

Indoleamine 2,3-dioxygenase mediates LPS-induced anxiety-like behavior in the open field test. After pretreatment with either vehicle or 1-methyltryptophan, the effects of LPS on (A) body weight and (B) locomotor activity over a 24h interval. (C) The duration of time spent within the central area or (D) in close proximity to the chamber walls was measured in the open field test at 24h post-LPS challenge. (F) The duration of time spent exploring the illuminated side of a light-dark box was also measured in different mice 24h post-LPS. Data represent group means ± SEM, n=7–12 mice per group in at least two independent experimental replications. *p<0.05 versus same pretreatment saline control, #p<0.05 versus 1MT/LPS.

Indoleamine 2,3-dioxygenase mediates LPS-induced anxiety-like behavior in the open field test. After pretreatment with either vehicle or 1-methyltryptophan, the effects of LPS on (A) body weight and (B) locomotor activity over a 24h interval. (C) The duration of time spent within the central area or (D) in close proximity to the chamber walls was measured in the open field test at 24h post-LPS challenge. (F) The duration of time spent exploring the illuminated side of a light-dark box was also measured in different mice 24h post-LPS. Data represent group means ± SEM, n=7–12 mice per group in at least two independent experimental replications. *p<0.05 versus same pretreatment saline control, #p<0.05 versus 1MT/LPS.