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. Author manuscript; available in PMC: 2013 Aug 1.

Published in final edited form as: Horm Behav. 2012 Mar 31;62(3):202–209. doi: 10.1016/j.yhbeh.2012.03.010

Peripheral administration of L-kynurenine dose-dependently precipitates anxiety-like behavior in the open field test. Mice were injected subcutaneously with the indicated doses of L-kynurenine. Two hours later, (A) exploratory locomotor activity, (B) time spent in the central area and (C) time spent in close proximity to the chamber wall was measured in the open field test. Data represent group means ± SEM, n=6–7 mice per group in at least two independent experimental replications. *p<0.05 and **p<0.01 versus all other treatment groups.

Peripheral administration of L-kynurenine dose-dependently precipitates anxiety-like behavior in the open field test. Mice were injected subcutaneously with the indicated doses of L-kynurenine. Two hours later, (A) exploratory locomotor activity, (B) time spent in the central area and (C) time spent in close proximity to the chamber wall was measured in the open field test. Data represent group means ± SEM, n=6–7 mice per group in at least two independent experimental replications. *p<0.05 and **p<0.01 versus all other treatment groups.