Table 2.
Genetic risk scores derived from different autoimmune diseases, in patients with GPA compared to controls.
| Disease* | Number of Risk Alleles in GRS† | Cohort | GRS in GPA cases Mean ± SD (Range)‡ | GRS in Controls Mean ± SD (Range)‡ | Separate Cohorts | Meta-analysis | ||
|---|---|---|---|---|---|---|---|---|
| Odds Ratio (95% CI)§ | P | Odds Ratio (95% CI)§ | P | |||||
| Celiac | 14 | W | 11.4 ± 2.23 (5–19) | 11.3 ± 2.42 (5–18) | 1.02 (0.96–1.08) | 0.54 | 1.02 (0.99–1.06) | 0.20 |
| T | 10.9 ± 2.39 (4–21) | 10.8 ± 2.43 (4–19) | 1.03 (0.98–1.07) | 0.25 | ||||
| CD | 57 | W | 50.2 ± 4.74 (37–62) | 50.2 ± 4.84 (36–67) | 1.00 (0.98–1.03) | 0.83 | 1.00 (0.99–1.02) | 0.63 |
| T | 49.3 ± 4.57 (35–64) | 49.2 ± 4.71 (35–66) | 1.01 (0.98–1.03) | 0.66 | ||||
| RA | 23 | W | 21.1 ± 3.00 (13–31) | 20.7 ± 3.08 (12–32) | 1.05 (1.01–1.10) | 0.025 | 1.05 (1.02–1.08) | 5.1E-05 |
| T | 21.0 ± 2.89 (11–30) | 20.6 ± 3.06 (12–31) | 1.05 (1.02–1.09) | 0.005 | ||||
| SLE | 22 | W | 17.7 ± 3.03 (9–26) | 17.5 ± 2.99 (9–28) | 1.02 (0.98–1.07) | 0.32 | 1.03 (1.00–1.06) | 0.07 |
| T | 17.0 ± 2.83 (9–24) | 16.7 ± 2.86 (8–26) | 1.03 (0.99–1.07) | 0.11 | ||||
| T1D | 32 | W | 31.2 ± 3.55 (23–41) | 31.2 ± 3.84 (22–44) | 1.00 (0.97–1.04) | 0.95 | ND | |
| T | 29.4 ± 3.54 (19–39) | 28.5 ± 3.52 (18–41) | 1.07 (1.04–1.11) | <0.001 | ||||
| UC | 11 | W | 11.4 ± 2.21 (5–17) | 11.4 ± 2.15 (6–18) | 0.98 (0.93–1.06) | 0.85 | 1.00 (0.96–1.04) | 0.95 |
| T | 11.4 ± 2.21 (5–19) | 11.4 ± 2.20 (4–20) | 1.00 (0.96–1.06) | 0.94 | ||||
Genetic risk scores (GRSs) were calculated separately for each listed disease. CD = Crohn’s disease; RA = rheumatoid arthritis; SLE = systemic lupus erythematosus; T1D = Type 1 diabetes; UC = ulcerative colitis.
The number of independent SNPs in the GRS is shown; the maximum possible GRS is twice this number, since homozygous risk alleles are counted twice.
Among 424 cases and 469 controls in WGGER (including CEU controls), or 456 cases and 1500 controls in Toronto.
Odds ratio indicates the increase in odds of having GPA associated with a 1-unit increase in GRS, determined by logistic regression with inclusion of the first two principal components as independent variables. CI = confidence interval.