Table 4.
Single GF release systems in bone regeneration.
| Single growth factor system |
Carrier | Species | Model | Ref. |
|---|---|---|---|---|
| BMP-2 | Heparin/apatite-coated Titanium implant |
Rat | Tibial defect | [231] |
| Autogenic graft | Human | Tibia non-union | [232] | |
| Collagen | Goat | Closed tibia fracture | [233] | |
| PLA coating | Sheep | Spine fusion | [234] | |
| Collagen | Rat | Femoral defect | [235] | |
| Alginate | Rat | Femoral defect | [236] | |
| BMP-7 | Collagen | Baboon | Calvarial defect | [237] |
| BMP-3 | Hydroxyapatite/TCP | Rat | Segmental femoral defect | [238] |
| BMP-13 | Collagen | Rat | Intramuscular tendon defect | [239] |
| TGF-β1 | Demineralized bone matrix/ carboxymethyl cellulose |
Rabbit | Calvarial defect | [240] |
| TCP+bone marrow | Rabbit | Radius defect | [241] | |
| TGF-β2 | Bolous/BSA solution | Rabbit | Tibia fracture | [242] |
| TGF-β3 | TCP | Baboon | Spine defect | [243] |
| IGF-I | osmotic pump device | Rat | Calvarial defect | [244] |
| PLGA microparticles | Sheep | Tibia defect, diaphyseal defect | [245] | |
| PLA coating | Minipig | Tibia defect | [246] | |
| IGF-II | Collagen | Rat | Facial defect | [247] |
| Basic-FGF | Injectable composite | Rabbit | Segmental defect | [248] |
| Hyaluronan gel | Baboon | Fibula defect | [249] | |
| Gelatin hydrogel | Dog | Maxillary furcation defect | [250] | |
| Acidic-FGF | Agarose | Rat | Calvarial defect | [251] |
| PDGF BB | Collagen | Rabbit | Tibia defect | [252] |
| Chitosan/TCP | Rat | Calvarial defect | [253] | |
| GDF-5 | Collagen | Rat | Femoral defect | [235] |
| VEGF | PLGA scaffolds | Rat | Calvarial defect | [254] |