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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Adv Drug Deliv Rev. 2012 May 22;64(12):1257–1276. doi: 10.1016/j.addr.2012.05.006

Table 5.

Limitations of single GF systems.

Drawbacks Implications
- Control of
cellular
behavior		 - Inadequate control of : migration,
proliferation, differentiation,
morphogenesis, apoptosis
Single growth
factor		 - Inability to mimic dynamics of
physiological cell signal controls
- Co-activation/
priming		 - Reduced bioactivity of cells due to
insufficient activation and crosstalk
- Receptor dimerization