TABLE 4.
Sex-based differences in whole-body oxygen consumption and IgE
| Parameter | Male |
Female |
||
|---|---|---|---|---|
| WT | KO | WT | KO | |
| Vo2 (ml/h) | 113.36 ± 11.49 | 112.04 ± 5.01 | 101.42 ± 8.59 | 93.55 ± 4.99 |
| IgE (ng/ml) | 57 ± 110 | 46 ± 64 | 819 ± 578 | 1099 ± 838 |
Whole-body oxygen consumption (Vo2) was reduced in knockout (KO) females compared to wild-type (WT) females, whereas males did not show such a pattern. IgE levels also suggested a COX4i2-knockout sex-dependent effect, with a trend to increasing levels in the KO females but not males compared to WT mice.