Table 1.
Protein |
ORF K. lactis |
ORF S. cerevisiae |
Function |
---|---|---|---|
Sir2 | YDL042C | KLLA0F14663g | NAD+ -dependent histone deacetylase |
Tpk1 | YJL164C | KLLA0B12716g | PKA catalytic subunit |
Tpk2 | YPL203W | KLLA0D03190g | PKA catalytic subunit |
Tpk3 | YKL166C | KLLA0B07205g | PKA catalytic subunit |
Bcy1 | YIL033C | KLLA0E04181g | PKA regulatory subunit |
Ypk3 | YBR028C | KLLA0F24618g | An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner |
Asa1 | YPR085C | KLLA0D09086g | Subunit of the ASTRA complex involved in the stability or biogenesis of PIKK*s such as TORC1 |
Tor1 | YJR066W | KLLA0B13948g | PIK-related protein kinase and rapamycin target, subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport, and autophagy, involved in meiosis |
Tor2 | YKL203C | KLLA0B13948g | PIK-related protein kinase and rapamycin target, subunit of TORC1 and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton, involved in meiosis |
Nnk1 | YKL171W | KLLA0A06776g | Protein kinase, implicated in proteasome function, interacts with TORC1, Ure2, and Gdh2 |
Tco89 | YPL180W | KLLA0E18855g | Subunit of TORC1 (Tor1 or Tor2-Kog1-Lst8-Tco89) |
Kog1 | YHR186C | KLLA0A09471g | Subunit of TORC1, it may act as a scaffold protein to couple TOR and its effectors |
Tti1 | YKL033W | KLLA0F25762g | Subunit of the ASTRA complex, involved in chromatin remodeling, telomere length regulator involved in the stability or biogenesis of PIKK*s such as TORC1 |
Tti2 | YJR136C | KLLA0B04026g | Subunit of the ASTRA complex, involved in chromatin remodeling, telomere length regulator involved in the stability or biogenesis of PIKK*s such as TORC1 |
Sch9 | YHR205W | KLLA0B03586g | AGC family protein kinase and functional ortholog of mammalian S6 kinase, phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase, integrates nutrient signals and stress signals from sphingolipids to regulate life span |
Maf1 | YDR005C | KLLA0E17535g | Negative regulator of RNA polymerase III, binds to the N-terminal domain of the Rpc160 subunit of Pol III to prevent closed-complex formation, localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9 |
Tel2 | YGR099W | KLLA0D15158g | Subunit of the ASTRA complex, involved in the stability or biogenesis of PIKK*s such as TORC1 |
Sfp1 | YLR403W | KLLA0B03047g | Regulates transcription of ribosomal protein, response to nutrients and stress, G2/M transitions during mitotic cell cycle, and DNA-damage response and modulates cell size, regulated by TORC1 and Mrs6 prion |
Npr2 | YEL062W | KLLA0D01067g | Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation |
Npr3 | YHL023C | KLLA0F18238g | Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation |
*PIKK phosphoinositide 3-kinase related kinase.