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. 2012 Jul 2;2012:634674. doi: 10.1155/2012/634674

Table 1.

Putative main actors of aging and its signaling pathways in K. lactis and S. cerevisiae. Degree of identity (%) between homologs is indicated in Figure 2.


Protein
ORF

K. lactis
ORF
S. cerevisiae
Function
Sir2 YDL042C KLLA0F14663g NAD+ -dependent histone deacetylase
Tpk1 YJL164C KLLA0B12716g PKA catalytic subunit
Tpk2 YPL203W KLLA0D03190g PKA catalytic subunit
Tpk3 YKL166C KLLA0B07205g PKA catalytic subunit
Bcy1 YIL033C KLLA0E04181g PKA regulatory subunit
Ypk3 YBR028C KLLA0F24618g An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner
Asa1 YPR085C KLLA0D09086g Subunit of the ASTRA complex involved in the stability or biogenesis of PIKK*s such as TORC1
Tor1 YJR066W KLLA0B13948g PIK-related protein kinase and rapamycin target, subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport, and autophagy, involved in meiosis
Tor2 YKL203C KLLA0B13948g PIK-related protein kinase and rapamycin target, subunit of TORC1 and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton, involved in meiosis
Nnk1 YKL171W KLLA0A06776g Protein kinase, implicated in proteasome function, interacts with TORC1, Ure2, and Gdh2
Tco89 YPL180W KLLA0E18855g Subunit of TORC1 (Tor1 or Tor2-Kog1-Lst8-Tco89)
Kog1 YHR186C KLLA0A09471g Subunit of TORC1, it may act as a scaffold protein to couple TOR and its effectors
Tti1 YKL033W KLLA0F25762g Subunit of the ASTRA complex, involved in chromatin remodeling, telomere length regulator involved in the stability or biogenesis of PIKK*s such as TORC1
Tti2 YJR136C KLLA0B04026g Subunit of the ASTRA complex, involved in chromatin remodeling, telomere length regulator involved in the stability or biogenesis of PIKK*s such as TORC1
Sch9 YHR205W KLLA0B03586g AGC family protein kinase and functional ortholog of mammalian S6 kinase, phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase, integrates nutrient signals and stress signals from sphingolipids to regulate life span
Maf1 YDR005C KLLA0E17535g Negative regulator of RNA polymerase III, binds to the N-terminal domain of the Rpc160 subunit of Pol III to prevent closed-complex formation, localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9
Tel2 YGR099W KLLA0D15158g Subunit of the ASTRA complex, involved in the stability or biogenesis of PIKK*s such as TORC1
Sfp1 YLR403W KLLA0B03047g Regulates transcription of ribosomal protein, response to nutrients and stress, G2/M transitions during mitotic cell cycle, and DNA-damage response and modulates cell size, regulated by TORC1 and Mrs6 prion
Npr2 YEL062W KLLA0D01067g Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation
Npr3 YHL023C KLLA0F18238g Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation

*PIKK phosphoinositide 3-kinase related kinase.