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. Author manuscript; available in PMC: 2013 Jul 1.

Published in final edited form as: Xenotransplantation. 2012 Jul;19(4):233–243. doi: 10.1111/j.1399-3089.2012.00712.x

In humans (A), baboons (B), and monkeys (C), platelet aggregation with ristocetin at 1mg/ml was dose-and dilution-dependent. Ristocetin (at 1mg/ml) induced significantly greater aggregation in undiluted blood than in 75% diluted blood in all three species. Ristocetin induced significantly greater aggregation in 50% diluted blood than in 75% diluted blood only in humans. In all three species, ristocetin at 0.5mg/ml induced dilution-dependent aggregation, but significant differences were only observed in monkeys. Values of mean percentage (%) of aggregation are indicated in the figure. (*p<0.05, **p<0.01, ***p<0.001).

In humans (A), baboons (B), and monkeys (C), platelet aggregation with ristocetin at 1mg/ml was dose-and dilution-dependent. Ristocetin (at 1mg/ml) induced significantly greater aggregation in undiluted blood than in 75% diluted blood in all three species. Ristocetin induced significantly greater aggregation in 50% diluted blood than in 75% diluted blood only in humans. In all three species, ristocetin at 0.5mg/ml induced dilution-dependent aggregation, but significant differences were only observed in monkeys. Values of mean percentage (%) of aggregation are indicated in the figure. (*p<0.05, **p<0.01, ***p<0.001).