Table 5. Association of alcohol drinking and tobacco smoking with risk of haematological malignancies: trend analysis excluding the first 3 years of follow-up.

	Alcohol				Smoking
	Trend among drinkers a				Trend among never- or current smokers b
Excluding first 3 years of follow-up	Cases	RR	95% CI	P trend	Cases	RR	95% CI	P trend
All haematological malignancies
ICD-O-3 classification	5235	0.94	0.89, 0.98	0.006	4825	1.14	1.09, 1.18	<0.001
ICD-10 classification	4528	0.92	0.87, 0.97	0.001	4170	1.07	1.03, 1.12	0.001
Subgroups of ICD-O-3 classification
ICD-O-3 haematological malignanciesc	Phet=0.01				Phet<0.001
Lymphoid	4031	0.91	0.86, 0.96	<0.001	3721	1.07	1.02, 1.12	0.006
Myeloid	1177	1.04	0.95, 1.15	0.4	1082	1.36	1.26, 1.47	<0.001
ICD-O-3 lymphoid malignancies	Phet=0.2				Phet<0.001
Hodgkin lymphoma	129	1.07	0.79, 1.44	0.7	152	1.57	1.29, 1.90	<0.001
Mature B cell	3045	0.90	0.84, 0.95	<0.001	2774	1.00	0.95, 1.06	0.9
Mature T cell	118	1.19	0.88, 1.61	0.3	88	1.34	1.02, 1.77	0.03
Other/unspecified lymphoid	739	0.88	0.78, 1.00	0.05	707	1.17	1.06, 1.30	0.002
ICD-O-3 mature B-cell malignancies	Phet=0.01				Phet=0.2
Diffuse large B-cell lymphoma	699	0.83	0.72, 0.95	0.005	650	1.03	0.92, 1.16	0.6
Follicular lymphoma	590	0.88	0.76, 1.02	0.08	542	1.08	0.96, 1.22	0.2
Plasma cell neoplasms	901	0.83	0.74, 0.94	0.002	820	0.92	0.83, 1.02	0.1
CLL/SLL	540	0.97	0.83, 1.12	0.6	494	0.96	0.84, 1.10	0.6
Other/unspecified mature B cell	315	1.19	0.99, 1.43	0.07	268	1.10	0.93, 1.30	0.3
ICD-O-3 myeloid malignanciesc	Phet=0.4				Phet<0.001
Acute myeloid leukaemia	343	0.98	0.81, 1.17	0.8	311	1.07	0.91, 1.26	0.4
Myeloproliferative/myelodysplastic disease	821	1.07	0.95, 1.21	0.2	759	1.48	1.35, 1.62	<0.001
Subgroups of ICD-10 classification
ICD-10 haematological malignancies	Phet=0.06				Phet<0.001
Hodgkin lymphoma	129	1.07	0.79, 1.44	0.7	152	1.57	1.29, 1.90	<0.001
Non-Hodgkin lymphoma	2435	0.89	0.83, 0.96	0.001	2227	1.12	1.05, 1.18	<0.001
Myeloma	947	0.86	0.76, 0.96	0.008	856	0.92	0.83, 1.02	0.1
Leukaemia	1017	1.03	0.93, 1.14	0.6	935	1.03	0.94, 1.13	0.5

Abbreviations: Cases, number of incident cases; CI, confidence interval; CLL/SLL, chronic lymphocytic leukaemia/small lymphocytic lymphoma; ICD-O-3, International Classification of Diseases for Oncology 3rd edition; ICD-10, International Classification of Diseases 10th revision; P_het result of χ² contrast test for heterogeneity of trends between subtypes; Ref, referent; P_trend, result of test for categorical trend; RR, relative risk.

Myeloproliferative/myelodysplastic disease includes chronic myeloid leukaemia.

^aRelative risk per 10 g per day, adjusted for body mass index, height, smoking and socioeconomic status, and stratified by cancer registry region.

^bRelative risk per 10 cigarettes per day, adjusted for body mass index, height, alcohol consumption and socioeconomic status, and stratified by cancer registry region.

^cExcludes other/unspecified cases.