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. 2012 Jul 2;55(16):7104–7113. doi: 10.1021/jm3005288

Figure 1.

Figure 1

Inhibition of SIRT2-mediated deacetylation reactions by compound 1a. (A) Western blot analysis of the inhibition of SIRT2-mediated α-tubulin deacetylation by 1a. The concentration of 1a was 200 μM, and measurements were performed at 30 min and 1 h. (B) Inhibition by 1a of the SIRT2-mediated deacetylation of the acetylated peptide RSTGGK(Ac)APRKQ. The reaction was detected by formation of the reaction product 14C-nicotinamide.