Table 1.
In Vitro Anticancer Activity Data for Seri of Compounds 4a–4d
| Entry | HCT-15 IC50 (μM) | MCF-7 IC50 (μM) |
|---|---|---|
| 4a | 3.5 | 4.5 |
| 4b | 13 | 15 |
| 4c | 10 | 12 |
| 4d | 10 | 9 |
Dose of the compound required to inhibit cell growth by 50% compared to untreated cell controls; values are derived from half maximal inhibitory concentration (IC50) graphs. All experiments were done in triplicate wells and each experiment was repeated thrice.
4a, dimethyl 5-acetyl-4-methyl- 6-(4-methoxyphenylimino)-6H-thiopyran-2,3-dicarboxylate; 4b, dimethyl 5-acetyl-4-methyl-6-(3-fluorophenylimino)-6H-thiopyran-2,3-dicarboxylate; 4c, diethyl 5-acetyl-4-methyl-6-(3-bromophenylimino)-6H-thiopyran-2,3-dicarboxylate; and 4d, dimethyl 5-acetyl-4-methyl-6-(phenylimino)-6Hthiopyran-2,3-dicarboxylate].