Table 1.
Pharmacokinetic colesevelam/drug interactions
| Drug | Cmax | AUC | Notes |
|---|---|---|---|
| Digoxin8 | -- | -- | |
| Ethynilestradiol9 | ↓ | ↓ | 4 hours before OK |
| Fenofibrate10 | -- | -- | Fenofibric acid assay |
| Glyburide9 | ↓ | ↓ | 4 hours before OK |
| Levothyroxine11 | ↓ | ↓ | 4 hours before OK |
| Lovastatin12 | -- | -- | |
| Metoprolol8 | -- | -- | |
| Norenthindrone9 | ↓ | -- | 1 hour before OK |
| Pioglitazone9 | -- | -- | |
| Quinidine8 | -- | -- | |
| Repaglinide9 | ↓ | -- | 1 hour before OK |
| Valproic acid8 | -- | -- | |
| Verapamil8 | ↓ | -- | Cmax ↓ borderline |
| Warfarin8 | -- | -- |
Notes: -- indicates bioavailability of drug unaffected by concomitant administration of colesevelam; ↓ indicates a decrease when given concomitantly with colesevelam relative to the study drug given alone.
Abbreviations: AUC, area under the curve; Cmax, maximum concentration.