Figure 2.

Inhibitory effects of chlorhexidine gluconate ointment on comedone formation. (A) Dermatoscopic findings on days 0 and 21 for rabbit ear skin treated with 50% oleic acid and liquid paraffin (control group) or with 50% oleic acid and chlorhexidine gluconate ointment (treatment group). (B) Histological findings of hair pores treated with 50% oleic acid and liquid paraffin (control group), and with 50% oleic acid and chlorhexidine gluconate ointment (treatment group) on day 21. Bar = 200 μm. (C) Quantitative assessment of the inhibitory effects of treatment on comedone formation.

Notes: Comedone size was measured for 20 comedones per ear of each rabbit to compare the effects of chlorhexidine gluconate ointment and liquid paraffin (n = 120 total comedones). *P < 0.001, **P < 0.005. The experiments were performed twice with similar results.