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. Author manuscript; available in PMC: 2012 Aug 23.
Published in final edited form as: Gen Comp Endocrinol. 2010 Feb 4;168(2):174–180. doi: 10.1016/j.ygcen.2010.01.019

Fig. 4.

Fig. 4

TR is sufficient to mediate the metamorphic effects of TH. Wild type tadpoles and sibling tadpoles transgenic for a dominant positive TR (dpTR) under the control of a heat shock-inducible promoter were reared together in methimazole to block endogenous T3 synthesis and were heat-shocked daily for 8 days. For comparison, wild type tadpoles were treated with TH for 3 days. Note that the heat shock induction of dpTR expression resulted in metamorphic events, including gill resorption (bracket) and limb outgrowth (arrowhead) in the transgenic (middle) but not wild type (top) animals, just like TH-treatment of wild type sibling animals (bottom) (Buchholz et al., 2004).