Table 1.
Comparison of the frequency of downregulation of the HLA-A and -B alleles most frequently expressed on leukemic cells
| Patients | Frequency of HLA class I allele downregulation (MFI ratio < 1) (%) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| A1 | A2 | A3 | A24 | A28 | B5 (B51, 52) | B7 | B8 | B44 | |
| AML | 0/3 (0.0) | 2/9 (22.2) | 4/9 (44.4) | 2/4 (50.0) | 1/3 (33.3) | 1/6 (16.7) | 4/5 (80.0) | 0/3 (0.0) | 6/6* (100.0) |
| B-ALL | 1/4 (25.0) | 1/6 (16.7) | 0/4 (0.0) | 0/1 (0.0) | 0/4 (0.0) | 2/4 (50.0) | 0/3 (0.0) | 1/2 (50.0) | 1/2 (50.0) |
| B-CLL | 5/6 (83.6) | 9/11 (81.8) | 5/6 (83.3) | 2/2 (100.0) | 1/1 (100.0) | 3/3 (100.0) | 0/2 (0.0) | 4/5 (80.0) | 4/6 (66.7) |
Differences in the frequency of downregulation between common HLA alleles in each leukemic patient group were tested by Fisher exact test. Significance is indicated using *