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. Author manuscript; available in PMC: 2012 Aug 23.
Published in final edited form as: Tissue Antigens. 2008 Nov;72(5):431–440. doi: 10.1111/j.1399-0039.2008.01118.x

Table 1.

The characteristics of anti-MICA mAbs

Characteristic: forms of MIC/methods to detect/alleles of MIC Anti-MICAmAbs
WW2G8 WW6B7 WW9B8 WJ1
Native form of MIC
    Cell ELISA
        HeLa cells + + + + ++++ ++++ ND
    Flow cytometry
        Me1386 cells - + - ND
        HeLa cells + + + ND
        MICA*00201 + + ND ND
        00701 + + ND ND
        00801 + + ND ND
        MICB*003 - + ND ND
        00502 - + ND ND
        008 - + ND ND
Denatured form of MIC Immunohistochemistry
        HeLa + ++++ ++++ ++++
    Western blot
        MICA*00201 ++ ++++ ++++ ++++
        004 + ++++ ++++ ++++
        00701 +/- + + -
        00801 + +++ ++++ +++
        00901 - + - +
        010 - + + +
        01201 + ++++ +++ ++++
        017 - + - +
        01801 - ++++ ++++ ++++
        019 - - - -
        045 - + + +
        MICB*002 - + - +
        003 - - - -
        004 - +++ - +++
        00502 - +++ - +++
        008 - +++ - +++
        013 - +++ - +++

MICA, major histocompatibility complex class I chain-related gene A; MICB, major histocompatibility complex class I chain-related gene B; mAbs, monoclonal antibodies; ELISA, enzyme-linked immunosorbent assay; ND, not determined.