Table III.

Comparison of the maternal plasma and serum concentrations of sVEGFR-1, sVEGFR-2, PlGF and sEng in patients with a normal pregnancy in the first, second and third trimester

Analyte	Plasma (n=70)	Serum (n=70)	p*
First trimester	n=10	n=10
sVEGFR-1 (pg/mL)	1,403.7 (264.8–3,259.1)	1,699.6 (277.7–3,568.9)	0.005
sVEGFR-2 (pg/mL)	10,178.8 (6,916.3–11,100.4)	10,708.6 (7,183.5–11,804.7)	0.04
PlGF (pg/mL)	27 (6.8–58.9)	29.2 (6.8–50.5)	0.5
sEng (ng/mL)	7.3 (6.4–12)	7.3 (5.8–11.3)	0.1
Second trimester	n=22	n=22
sVEGFR-1 (pg/mL)	1,542.9 (386.0–4,133.6)	1,698.7 (512.2–4,686.2)	<0.001
sVEGFR-2 (pg/mL)	8,970.9 (6,673.4–13,787.5)	10,192.9 (6,469.5–13,573.9)	<0.001
PlGF (pg/mL)	145.3 (26.1–1,896.3)	157.3 (27.3–1,841.8)	0.5
sEng (ng/mL)	6.5 (4.5–38.4)	6.6 (4.7–43.6)	0.6
Third trimester	n=38	n=38
sVEGFR-1 (pg/mL)	2,793.3 (827.1–19,210.9)	3,083.3 (885–15,861.8)	<0.001
sVEGFR-2 (pg/mL)	8,996.4 (6,201.1–13,817.8)	9,947.8 (3,379.4–16,168)	0.003
PlGF (pg/mL)	304.4 (39.9–1,606.3)	292.1 (41.8–1,540)	0.2
sEng (ng/mL)	10 (5.6–34.9)	10.1 (5.6–44.9)	1.0

The results are expressed as median (range)

^*Wilcoxon ranks test