Table 2.
Histopathology and virus titers in ferret organs
| Challenge virus |
Organ/tissue | Virus titer (log10 PFU/ml)1 |
Histopathology score in the lung2 |
|---|---|---|---|
| HAmut | Nasal turbinate | 6.62 | |
| Lung | 5.40 (4/5) | 12.5 (4/4) | |
| Trachea | 5.67 | ||
| Small intestine | – | ||
| Spleen | – | ||
| Liver | – | ||
| PAmut | Nasal turbinate | 5.41 | |
| Lung | 4.46 (2/4) | 14 (3/4) | |
| Trachea | 4 | ||
| Small intestine | – | ||
| Spleen | – | ||
| Liver | – | ||
| HAmutPAmut | Nasal turbinate | 6.48 | |
| Lung | 4.52 (4/4) | 17.75 (4/4) | |
| Trachea | 6.62 | ||
| Small intestine | 2.04 | ||
| Spleen | – | ||
| Liver | – | ||
1
Organs were sampled from a single ferret in each group. For the lung, mean viral titer for the 4 to 5 lung lobes sampled per ferret. Number of lung lobes positive/total number of lobes tested is indicated in parenthesis.
2
Scores indicated correspond to mean scores for symptomatic ferret lung lobes tested. Lesions were scored from 0 to 29 taking into account the percentage of tissue involved (scored from 0 to 3 for none to >75%) and the lesion intensity (0 for none to 3 for diffuse or compact) in the bronchi, submucosal glands, bronchioles, alveoli, and interstitium. Number of lung lobes positive/total number of lobes tested is indicated in parenthesis.