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(A) Biochemical functions of the PcG complexes PRC2 and PRC1. PRC2 mediates the trimethylation of histone H3K27, a repressive histone mark. PRC1 binds H3K27me3 and compacts chromatin. (B) Biochemical functions of TrxG complexes MLL and BAF. MLL mediates trimethylation of histone H3K4. BAF has chromatin remodeling activity.
