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The adult heart responds to stress, such as pressure overload or β-adrenergic stimulation, by hypertrophic growth of cardiomyocytes. This results in thickened myocardial walls and smaller ventricular chamber(s). The PcG protein Ezh2 represses cardiac hypertrophy through a Six1-dependent pathway. The TrxG protein Brg1 is required for development of the hypertrophic response.
