Table 3.

Affinities of Screening Hits as Determined by Displacement of bt-TAR-32 Binding to TDP-43

Compound	IC50 (95% CI), μM
1	0.12 (0.067–0.21)
2	0.15 (0.065–0.33)
3	0.28 (0.19–0.42)
4	0.47 (0.29–0.76)
5	0.50 (0.25–1.0)
6	0.71 (0.49–1.0)
7	1.1 (0.65–1.2)
8	1.2 (0.5–2.9)
9	1.3 (1.2–1.5)
10	3.9 (2.8–5.5)
11	>10

Values shown are the geometric means with 95% confidence intervals of 3 determinations.