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The figure shows gross massive swelling, discoloration and deformity of the kidneys following adenine-induced CRF at 4 weeks compared to Control rats fed regular rat chow. Simultaneous administration of F1 has prevented this renal damage. CRF: Chronic Renal Failure rats were fed 0.7% adenine for 2 weeks followed by regular rat chow for 2 weeks; CRF + F1: animals were fed 0.7% adenine and F1, 0.5g/kg/day simultaneously for 2 weeks followed by regular rat chow for 2 additional weeks.
